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Reviewed, UniProtKB/Swiss-Prot Q9QZF2 (GPC1_MOUSE)

Last modified November 25, 2008. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glypican-1
Cleaved into the following chain:
    1- Recommended name:
            Secreted glypican-1
Gene names
Name: Gpc1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Cell surface proteoglycan that bears heparan sulfate. May play an important role in the trophic and injury responses of neurons By similarity.

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor; Extracellular sideBy similarity.

Secreted glypican-1: Secreted › extracellular spaceBy similarity.

Post-translational modification

This cell-associated glypican is further processed to give rise to a medium-released species By similarity.

Sequence similarities

Belongs to the glypican family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 529506Glypican-1
PRO_0000012297
Chain24 – ?Secreted glypican-1PRO_0000333838
Propeptide530 – 55728Removed in mature form Potential
PRO_0000012298

Amino acid modifications

Lipidation5291GPI-anchor amidated serine Potential
Glycosylation551O-linked (Xyl...) (heparan sulfate) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation4851O-linked (Xyl...) (heparan sulfate) Potential
Glycosylation4871O-linked (Xyl...) (heparan sulfate) Potential
Glycosylation4891O-linked (Xyl...) (heparan sulfate) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q9QZF2-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 58A9A24955D16A0B

FASTA55761,360
        10         20         30         40         50         60 
MELRTRGWWL LCAAAALVVC ARGDPASKSR SCSEVRQIYG AKGFSLSDVP QAEISGEHLR 

        70         80         90        100        110        120 
ICPQGYTCCT SEMEENLANH SRMELESALH DSSRALQATL ATQLHGIDDH FQRLLNDSER 

       130        140        150        160        170        180 
TLQEAFPGAF GDLYTQNTRA FRDLYAELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP 

       190        200        210        220        230        240 
QLLPDDYLDC LGKQAEALRP FGDAPRELRL RATRAFVAAR SFVQGLGVAS DVVRKVAQVP 

       250        260        270        280        290        300 
LAPECSRAIM KLVYCAHCRG VPGARPCPDY CRNVLKGCLA NQADLDAEWR NLLDSMVLIT 

       310        320        330        340        350        360 
DKFWGPSGAE SVIGGVHVWL AEAINALQDN KDTLTAKVIQ ACGNPKVNPH GSGPEEKRRR 

       370        380        390        400        410        420 
GKLALQEKPS TGTLEKLVSE AKAQLRDIQD FWISLPGTLC SEKMAMSPAS DDRCWNGISK 

       430        440        450        460        470        480 
GRYLPEVMGD GLANQINNPE VEVDITKPDM TIRQQIMQLK IMTNRLRGAY GGNDVDFQDA 

       490        500        510        520        530        540 
SDDGSGSGSG GGCPDDTCGR RVSKKSSSSR TPLTHALPGL SEQEGQKTSA ATCPEPHSFF 

       550 
LLFLVTLVLA AARPRWR

« Hide

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References

« Hide 'large scale' references
[1]"Mapping of the rat glypican genes."
Szpirer C., Szpirer J., Riviere M., Van Vooren P., Veugelers M., David G.
Cytogenet. Cell Genet. 93:83-86(2001) [PubMed: 11474185] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF185613 mRNA. Translation: AAD56243.1.
BC062902 mRNA. Translation: AAH62902.1.
RefSeqNP_057905.1.
UniGeneMm.297976

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000034220. Mus musculus. [Contig view]
GeneID14733.
KEGGmmu:14733.

Organism-specific databases

MGIMGI:1194891. Gpc1.

Phylogenomic databases

HOGENOMQ9QZF2.
HOVERGENQ9QZF2.

Gene expression databases

ArrayExpressQ9QZF2.
CleanExMM_GPC1.
GermOnlineENSMUSG00000034220. Mus musculus.

Family and domain databases

InterProIPR001863. Glypican.
IPR015502. Gpc1.
[Graphical view]
PANTHERPTHR10822. Glypican. 1 hit.
PTHR10822:SF8. Gpc1. 1 hit.
PfamPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEPS01207. GLYPICAN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio286777.
SOURCESearch...

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Entry information

Entry nameGPC1_MOUSE
AccessionPrimary (citable) accession number: Q9QZF2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: May 1, 2000
Last modified: November 25, 2008
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents